Mrs. Essien purchased the Club at a fee of 237,000 euros (US$ 254,000) after completion of the transfer of ownership to her name.
The Philanthropist officially secured full ownership of the Club on Thursday after meeting with the former financiers of the Serie C outfit.
“Football Club Como is pleased to announce that the club has a new company taking charge of the affairs of the team," the club's official statement read.
"We are pleased to announce to the city of Como that Akosua Puni, Mrs. Essien, is the new owner Fc Como Srl.
"We will soon come to the city to introduce ourselves. We are honoured to be here and to join a club with over 100 years of history.
"We want to thank our curator Di Michele for the great job done. The commitments and promises are to grow first team and focus on youth development.
"We will create the conditions to bring the Como in Serie B as soon as possible and enhance our talents."
She thus becomes the first Ghanaian female football administrator to acquire a Club outside the country.
Como FC until recently have been hit with heavy financial burdens which saw the Club being relegated to serie C.